Revista Peruana de Medicina Integrativa

Actividad inhibitoria in vitro de extractos etanólicos de plantas del género Annona y Piper sobre promastigotes de Leishmania braziliensis

In vitro inhibitory activity of ethanolic extracts from Annona and Piper species on Leishmania braziliensis promastigotes

César M Fuertes

Instituto de Ciencias Farmacéuticas y Recursos Naturales “Juan de Dios Guevara”, Facultad de Farmacia y Bioquímica - UNMSM

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Resumen

Objetivo. Evaluar el efecto de extractos etanólicos de cinco especies del género Annona y cinco especies del género Piper frente a la línea clonal de referencia de promastigotes de Leishmania braziliensis. Materiales y métodos. Se evaluó el efecto de los extractos etanolicos de Annona hypoglauca, Annona montana, mucosa, Annona nítida, Annona squamosa, Piper acutifolium¸ Piper aduncum, Piper callosum, Piper carpunya y Piper peltatum; sobre cepas de promastigotes de Leishmania braziliensis MHON/BR/79/M2904. El efecto leishmanicida in vitro se evaluó mediante el cálculo del IC50 por el método probit. Resultados. Las especies con mayor actividad fueron P. acutifolium (IC50=19,40 μg/mL) P. peltatum (IC50=26,6 μg/mL), P. callosum (IC50=21,7 μg/mL), A. mucosa (IC50=30,5 μg/mL) y A. montana (IC50=16,4 μg/mL). Conclusión. Los extractos etanólicos de P. acutifolium, P. peltatum, P. callosum, A. mucosa y A. montana, han mostrado una actividad leishmanicida in vitro. Sin embargo, estos efectos no son superiores a los exhibidos por Anfotericina B.

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