Revista Peruana de Medicina Integrativa

Efecto del extracto de Corynaea crassa y selenio en la disfunción sexual inducida en Rattus norvegicus albinus

Effect of Corynaea crassa and Selenium extract on sexual dysfunction induced in rats

Fidel Acaro Chuquicaña

Laboratorio de Farmacología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.

https://orcid.org/0000-0002-7609-1717

Jorge Arroyo Acevedo

Laboratorio de Farmacología Experimental, Facultad de Medicina Humana, UNMSM, Lima, Perú. Instituto de Investigaciones Clínicas, UNMSM, Lima, Perú.

https://orcid.org/0000-0002-7695-1908

---

Resumen

Objetivo. Determinar el efecto erectógeno del extracto etanólico de las raíces de Corynaea crassa (EECC) y selenio en la disfunción sexual inducidas en roedores. Materiales y métodos. Investigación de diseño experimental, preclínico, in vivo, llevado a cabo en el Laboratorio de Farmacología Experimental de la Facultad de Medicina Humana-UNMSM, Lima, Perú. Se emplearon raíces de «viagra macho» colectada en el departamento de Cajamarca; ratas machos de dos meses, de 150 – 200 g; 42 animales se dividieron al azar en siete grupos: 1). SSF 5 mL/kg; 2). Sildenafilo 5 mg/kg/día; 3). EECC 100mg/kg; grupo 4 EECC 200 mg/kg; grupo 5 EECC 400 mg/kg; grupo 6 EECC 200mg/kg + Se 1 ug/kg y grupo 7 EECC 400 mg/kg + Se 1 ug/kg. Se evaluaron los parámetros del comportamiento sexual, reflejos del pene y nivel de testosterona. Resultados. Por análisis cualitativo se identificaron alcaloides, compuestos fenólicos, esteroides/terpenoides, flavonoides, lactonas, saponinas y taninos. El comportamiento sexual fue dosis dependiente; la administración de 400 mg/kg de EECC + Se 1 ug/kg por vía oral incrementó la frecuencia de monta, en tanto que la dosis de 100 mg/kg aumentó la frecuencia de intromisión (p<0,05), así como los parámetros de los reflejos del pene e incremento significativo de los niveles de testosterona. Conclusiones. Se ha demostrado efecto erectógeno del extracto etanólico de las raíces de Corynaea crassa más selenio en la disfunción sexual inducidas en ratas.

Palabras clave: Corynaea crassa; Viagra macho; Selenio; Disfunción sexual; Comportamiento sexual. 

---

Referencias

Penzias A, Bendikson K, Butts S, Coutifaris C, Falcone T, Fossum G. Diagnostic evaluation of sexual dysfunction in the male partner in the setting of infertility: a committee opinion. American Society for Reproductive Medicine. 2018; 110:833-7.

Kucukdurmaz F, Acar G, Resim S. Deterioration of Chronotropic Responses and Heart Rate Recovery Indices in Men With Erectile Dysfunction. Sex Med.2018; 6: 8-14. DOI: 10.1016/j.esxm.2017.10.002.

Wiggins A, Tsambarlis N, Abdelsayed G, Levine A. A Treatment Algorithm for Healthy Young Men with Erectile Dysfunction. BJU International. 2018; 123:173–179 DOI:10.1111/bju.14458.

Esfahani SB, Sebely P. Obesity, mental health, and sexual dysfunction: A critical review. Health Psychology Open. 2018: 1-13. DOI. org/10.1177/2055102918786867.

Dickenson J, Gleason N, Coleman E, Miner M. Prevalence of Distress Associated With Difficulty Controlling Sexual Urges, Feelings, and Behaviors in the United States. JAMA Netw Open. 2018; 1(7): e184468. DOI: 10.1001/jamanetworkopen.2018.4468.

Malca G, Henniga L, Sieler J, Bussmann R. Constituents of Corynaea crassa “Peruvian Viagra”. Revista Brasileira de Farmacognosia. 2015; 25, 92–97. DOI.org/10.1016/j.bjp.2015.02.007.

Xu F, Huang X, Wu H, Wang X. Beneficial health effects of lupenone triterpene: A review. Biomedicine & Pharmacotherapy. 2018; 103,198–203. DOI:10.1016/j.biopha.2018.04.019.

McGrath J, McLachlan E, Zeller R. Transparency in Research involving Animals: The Basel Declaration and new principles for reporting research in BJP manuscripts. Br J Pharmacol. 2015; 172(10): 2427–2432. DOI: 10.1111/bph.12956.

Yakubu MT, Atoyebi AR. Brysocarpus coccineus(Schum & Thonn) root reinstates sexual competence and testicular function in paroxetine-induced sexual dysfunction in male Wistar rats. Andrologia. 2018; 50(4), e12980. DOI:10.1111/and.12980.

Defo P, Wankeu-Nya M, Ngadjui E, Fozin G, Kemka F, Kamanyi A., Kamtchouing P, Watcho P. The methanolic extract of Guibourtia tessmannii (Caesalpiniaceae) improves sexual parameters in high fat diet-induced obese sexually sluggish rats. Asian Pacific Journal of Reproduction.2017; 6(5): 202-211.

Erhabor J, Idu M. Aphrodisiac potentials of the ethanol extract of Aloe barbadensis Mill. root in male Wistar rats. BMC Complement Altern Med. 2017; 17, 360. DOI: 10.1186/s12906-017-1866-1.

Kenmogne H, Koloko B, Hambe C, Domkam J, Ngaha Njila M, Bend, E, Oundoum P, Lembè D, Dimo, T. Effects of aqueous root extract of Carpolobia alba G. Donon sexual behaviour in adult male rats. Andrologia. 2015; 48 (8): 908–914. DOI:10.1111/and.12678.

Gajbhiye S, Jadhav K, Marathe P, Pawar D. Animal models of erectile dysfunction. Indian J Urol. 2015; 31 (1):15–21. DOI: 10.4103/0970-1591.128496.

Fouche G, Afolayan A, Wintola O, Khorombi T, Senabe, J. Effect of the aqueous extract of the aerial parts of Monsonia angustifolia E. Mey. Ex A. Rich., on the sexual behaviour of male Wistar rats. BMC Complementary and Alternative Medicine. 2015; 15:343. DOI: 10.1186/s12906-015-0880-4

Enema OJ, Umoh UF, Umoh RA, Ekpo EG, Adesina SK, Eseyin OA. Chemistry and Pharmacology of Aphrodisiac Plants: A Review. Journal of Chemical and Pharmaceutical Research. 2018; 10(7): 70-98.

Zhu W, Du Y, Meng H, Dong Y, Li L. A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestres. Chem Cent J. 2017; 11: 60. DOI: 10.1186/s13065-017-0289-x.

Jung M, Oh K, Choi E, Kim Y, Bae,D, Oh DR, Kim K, Dong-Wook Kim DW, Choi C. Effect of Aqueous Extract of Dendropanax morbifera Leaf on Sexual Behavior in Male Rats. Journal of Food and Nutrition Research. 2017; 5(7):518-521. DOI:10.12691/jfnr-5-7-10.

Besong E, Ateufack G, Babiaka S, Kamanyi A. Leaf-Methanolic Extract of Pseudopanax arboreus(Araliaceae) (L. F. Phillipson) Reverses Amitriptyline-Induced Sexual Dysfunction in Male Rats. Biochem Res Int. 2018. DOI: 10.1155/2018/2869727.

Heijkoop R, Huijgens PT, Snoeren EMS. Assessment of sexual behavior in rats: The potentials and pitfalls. Behavioural Brain Research. 2018; 352, 70–80. DOI:10.1016/j.bbr.2017.10.029.

Carro-Juárez M, Rodríguez-Santiago M, Franco M, Hueletl M. Aphrodisiac Activity of the Aqueous Crude Extract of Purple Corn (Zea mays) in Male Rats. Journal of Evidence-Based Complementary & Alternative Medicine. 2017; 22(4): 637-645. DOI: 10.1177/2156587217708521.

Tang X, Olatunji O, Zhou Y, Hou X. In vitro and in vivo aphrodisiac properties of the seed extract from Allium tuberosum on corpus cavernosum smooth muscle relaxation and sexual behavior parameters in male Wistar rats. BMC Complem Altern Med. 2017; 17, 510. DOI: 10.1186/s12906-017-2008-5.

Allouh M, Daradka H, Ghaida J. Influence of Cyperus esculentus tubers (Tiger Nut) on male rat copulatory behavior. BMC Complementary and Alternative Medicine. 2015; 15 (33):1-7. DOI: 10.1186/s12906-015-0851-9.

Kanyanga C, Wembonyama L, Muganzaa D, Munduku C, Kabangu O, Apers S, Vlietinck J, Pieters L. Effects of the lyophilized aqueous extract form the root bark of Perianthus longifolia miers (menispermaceae) on sexual behaviors of normal male wistar rats and its acute toxicity. World Journal of Pharmacy and Pharmaceutical Sciences. 2016; 5(4):135-155. DOI: 10.20959/wjpps20164-6278.

Usnale S, Biyani K. Preclinical aphrodisiac investigation of ethanol extract of Flueggea leucopyrus Willd. Leaves. The Journal of Phytopharmacology. 2018;7(3):319-324.

Sahin K, Orhan C, Akdemir F, Tuzcu M, Gencoglu H, Sahin N, Turk G, Yilmaz I, Ozercan IH, Juturu V. Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats. BMC Complement Altern Med. 2016; 16(1): 318. DOI: 10.1186/s12906-016-1303-x.

Wattanathorn J, Prabsattroo T, Somsapt P, Sritragool O, Thukham-mee W, Muchimapura S. Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions. Biomed Res Int. 2018; 1-13. DOI: 10.1155/2018/6452965.

Prabsattroo T, Wattanathorn J, Iamsaard S, Somsapt P, Sritragool O, Thukhummee W, Muchimapura S. Moringa oleifera extract enhances sexual performance in stressed rats. J Zhejiang Univ-Sci B (Biomed & Biotechnol). 2015; 16(3):179–190. DOI: 10.1631/jzus.B1400197.